Filed pursuant to Rule 424(b)(3)
                                                Registration No. 333-74604



PROSPECTUS SUPPLEMENT NO. 1 DATED FEBRUARY 11, 2002
TO PROSPECTUS DATED DECEMBER 13, 2001



                            PRO-PHARMACEUTICALS, INC.


                        2,650,462 Shares of Common Stock
                                 $.001 par value


     We are  using  this  prospectus  supplement  in  connection  with our "best
efforts"  offering of 1,428,572 shares of our common stock,  $.001 par value per
share.

     Extension of Offering  Period.  We are extending the offering of our common
stock from February 11, 2002 until April 12, 2002.

     You should read this  prospectus  supplement  together with our  prospectus
dated  December  13,  2001,  which  is  to be  delivered  with  this  prospectus
supplement.



          The date of this Prospectus Supplement is February 11, 2002.