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                                 UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                    FORM 144

                     NOTICE OF PROPOSED SALE OF SECURITIES
              PURSUANT TO RULE 144 UNDER THE SECURITIES ACT OF 1933

ATTENTION: TRANSMIT FOR FILING 3 COPIES OF THIS FORM CONCURRENTLY WITH EITHER
           PLACING AN ORDER WITH A BROKER TO EXECUTE A SALE OR EXECUTING A SALE
           DIRECTLY WITH A MARKET MAKER.

- ------------------------------------------------------------------------------------------------------------------------------------ 1(a) NAME OF ISSUER (Please type or print) (b) IRS IDENT. NO. (c) S.E.C. FILE NO. Pro-Pharmaceuticals, Inc. 04-3562325 - ------------------------------------------------------------------------------------------------------------------------------------ (d) ADDRESS OF ISSUER STREET CITY STATE ZIP CODE (e) TELEPHONE NO. ------------------------ 7 Wells Ave. Newton MA 02459 Area Code Number (617) 559-0033 - ------------------------------------------------------------------------------------------------------------------------------------ 2(a) NAME OF PERSON FOR WHOSE ACCOUNT THE (b) I.R.S. NO. (c) RELATIONSHIP (d) ADDRESS STREET CITY STATE ZIP CODE SECURITIES ARE TO BE SOLD TO ISSUER Bristol Investment Fund, Ltd. 98-0335509 Shareholder Caledonian Fund Services Limited, 69 Dr. Roy's Dr. George Town, Grand Cayman, Cayman Islands - ------------------------------------------------------------------------------------------------------------------------------------ INSTRUCTION: The person filing this notice should contact the issuer to obtain the I.R.S. Identification Number and the SEC File Number - ------------------------------------------------------------------------------------------------------------------------------ Name and Address of SEC USE Title of the Class Each Broker Through ONLY of Securities To whom the Securities Are --------- Number of Shares or Aggregate Market Be Sold (See instr. To Be Offered or Each Broker- Other Units To Be Value 3(a)) Market Maker who is Dealer Sold (See instr. 3(d)) Acquiring the Securities File (See instr. 3(c)) (See instr. 3(b)) Number - ------------------------------------------------------------------------------------------------------------------------------ Common Stock Citigroup Prime Broker 390 Greenwich Street, 3rd Floor 39,596 $45,931 New York, NY 10013 - ------------------------------------------------------------------------------------------------------------------------------ - ------------------------------------------------------------------------------------------------------------------------------ - ------------------------------------------------------------------------------------------------------------------------------ Number of Shares or Approximate Date of Name of Each Securities Other Units Sale Exchange Outstanding (See instr. 3(f)) (See instr. 3(g)) (See instr. (MO. DAY YR.) 3(e)) - ------------------------------------------------------------------------------------------------ 29,751,208 3/5/07 AMEX - ------------------------------------------------------------------------------------------------ - ------------------------------------------------------------------------------------------------ - ------------------------------------------------------------------------------------------------ INSTRUCTIONS: 1. (a) Name of issuer. (b) Issuer's IRS Identification Number. (c) Issuer's SEC file number, if any. (d) Issuer's address, including zip code. (e) Issuer's telephone number, including area code. 2. (a) Name of person for whose account the securities are to be sold. (b) Such person's or I.R.S. Identification number, if such a person is an entity. (c) Such person's relationship to the issuer (e.g., officer, director, 10 percent stockholder, or member of immediate family of any of the foregoing). (d) Such person's address, including zip code. 3. (a) Title of the class of securities to be sold (b) Name and address of each broker through whom the securities are intended to be sold. (c) Number of shares or other units to be sold (if debt securities, give the aggregate face amount). (d) Aggregate market value of the securities to be sold as of a specified date within 10 days prior to the filing of this notice. (e) Number of shares or other units of the class outstanding, or if debt securities the face amount thereof outstanding, as shown by the most recent report or statement published by the issuer. (f) Approximate date on which the securities are to be sold. (g) Name of each securities exchange, if any, on which the securities are intended to be sold. 2 TABLE I--SECURITIES TO BE SOLD Furnish the following information with respect to the acquisition of the securities to be sold and with respect to the payment of all or any part of the purchase price or other consideration therefor: - --------------------------------------------------------------------------------------------------------------------------------- Title of Date You Nature of Acquisition Name of Person From Amount of Date of Nature of Payment the Class Acquired Transaction Whom Acquired Securities Payment (If Gift, Also Give Acquired Date Donor Acquired) - --------------------------------------------------------------------------------------------------------------------------------- Common Stock 2/14/06 Convertible Note Issuer 39,596 2/14/06 Cash - --------------------------------------------------------------------------------------------------------------------------------- INSTRUCTIONS: 1. If the securities were purchased and full payment therefore was not made in cash at the time of purchase, explain in the table or in a note thereto the nature of the consideration given. If the consideration consisted of any note or other obligation, or if payment was made in installments describe the arrangement and state when the note or other obligation was discharged in full or the last installment paid. 2. If within two years after the acquisition of the securities the person for whose account they are to be sold had any short positions, put or other option to dispose of securities referred to in paragraph (d)(3) of Rule 144, furnish full information with respect thereto. ==================================================================================================================================== TABLE II--SECURITIES SOLD DURING THE PAST THREE MONTHS Furnish The Following Information as to All Securities of The Issuer Sold During The Past Three Months By The Person For Whose Account The Securities Are To Be Sold. - ------------------------------------------------------------------------------------------------------------------------------------ Name and Address of Seller Title of Securities Sold Date of Sale Amount of Gross Proceeds Securities Sold - ------------------------------------------------------------------------------------------------------------------------------------ - ------------------------------------------------------------------------------------------------------------------------------------ REMARKS: INSTRUCTIONS: See the definition of "person" in paragraph (a) of Rule 144. Information is to be given not only as to the person for whose account the securities are to be sold but also as to all other persons included in that definition. In addition, information shall be given as to sales by all persons whose sales are required by paragraph (e) of Rule 144 to be aggregated with sales for the account of the person filing this notice. March 5, 2007 ---------------------------------------- (DATE OF NOTICE) ATTENTION: The person for whose account the securities to which this notice relates are to be sold hereby represents by signing this notice that he does not know any material adverse information in regard to the current and prospective operations of the issuer of the securities to be sold which has not been publicly disclosed. Paul Kessler ---------------------------------------- (SIGNATURE) The notice shall be signed by the persons for whose account the securities are to be sold. At least one copy of the notice shall be manually signed. Any copies not manually signed shall bear typed or printed signatures. ATTENTION: INTERNATIONAL MISSTATEMENTS OR OMISSION OF FACTS CONSTITUTE FEDERAL CRIMINAL VIOLATIONS (SEE 18 U.S.C. 1001).