Providence Cancer Institute to Present Findings on GR-MD-02 at the 2019 Keystone Symposia on Molecular and Cellular Biology
Combination therapies with GR-MD-02 have been shown to improve the survival rate of tumor-bearing mice, reducing the percentage of suppressive myeloid cells (MDSC) as well as diminishing the cells’ suppressive capabilities. GR-MD-02 acts as an inhibitor of galectin-3, a molecule found in many tumors and associated with poor prognosis because it depresses immune response to the tumor. Under the direction of
“The results we’ve seen in Providence’s study are very encouraging in the treatment of metastatic melanoma and squamous cell head and neck cancer. We believe combination immunotherapy treatment using GR-MD-02 will offer new hope to patients and their families affected by these diseases,” said Dr.
During Providence’s Phase 1 trial, data showed a 50% objective response rate in advanced melanoma with GR-MD-02 in combination with KEYTRUDA, and a significant decrease in the frequency of suppressive MDSCs following treatment in the responding patients (on day 85 post-treatment) was observed compared to non-responders. The published data on KEYTRUDA alone has shown an objective response rate of 33% in this patient population. Providence’s pre-clinical models also show synergy of GR-MD-02 with T-cell co-stimulatory agents and further clinical translations of the basic science are planned.
Forward Looking Statements
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. These statements relate to future events or future financial performance and use words such as “may,” “estimate,” “could,” “expect” and others. They are based on management’s current expectations and are subject to factors and uncertainties that could cause actual results to differ materially from those described in the statements. These statements include those regarding the hope that Galectin’s development program for GR-MD-02 will lead to the first therapy for the treatment of fatty liver disease with cirrhosis and those regarding the hope that our lead compounds will be successful in cancer immunotherapy. Factors that could cause actual performance to differ materially from those discussed in the forward-looking statements include, among others,; that for the clinical trials in cancer immunotherapy, Galectin has relied on the trials undertaken by
Source: Galectin Therapeutics Inc.